← Perspectives
Twelve questions · Christian Roghi · August 2026

Beyond the usual frame.

Twelve questions to challenge familiar assumptions about the microbiome. Prompts to look again, not predictions.

Look again

01

What if the field’s biggest risk is not scientific failure, but commercial overreach?Featured on Perspectives

02

What if personalisation is the wrong frame, and context is the real one?

03

What if we never find a healthy microbiome, only healthy responses?

04

What if the scarce resource is not data, but interpretation?

Go deeper

05

What if we stopped trying to engineer the microbiome, and started designing around it instead?

06

What if microbiome trials keep failing because we are demanding one-size-fits-all evidence for a biology that is not one-size-fits-all?

07

What if the microbiome is not a signature, but a biography?

08

What if some unexplained variability in drug response has been microbiome variability all along?

Go wider

09

What if the food system is the largest unmanaged microbiome experiment we have ever run?

10

What if AI can predict the outcome without explaining the mechanism, and we have to decide whether that is enough?

11

What if soil health and gut health are different expressions of the same ecological problem?

12

What if we are not studying an organ, but a civilisation?